Murine malaria is associated with significant hearing impairment

Abstract Background Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice. Methods Twenty m...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Stephan Kurt, Reindl Markus, Glueckert Rudolf, Fischer Marlene, Dietmann Anelia, Lackner Peter, Kositz Christian H, Schmutzhard Joachim, Riechelmann Herbert, Schrott-Fischer Annelies, Schmutzhard Erich
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2010
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-9-159
https://doaj.org/article/95deb71b12ca42c09b81b9f376d7e600
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Summary:Abstract Background Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice. Methods Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness. Results A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used. Conclusion This suggests that malaria itself leads to a hearing impairment in mice.

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