The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidan...
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ftdoajarticles:oai:doaj.org/article:912f776f21244f148a5f1430f1277f29 2023-05-15T13:40:39+02:00 The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes Charlotte Wiles Marcus J. Hammond Paul Watts 2009-06-01T00:00:00Z https://doi.org/10.3762/bjoc.5.27 https://doaj.org/article/912f776f21244f148a5f1430f1277f29 EN eng Beilstein-Institut https://doi.org/10.3762/bjoc.5.27 https://doaj.org/toc/1860-5397 1860-5397 doi:10.3762/bjoc.5.27 https://doaj.org/article/912f776f21244f148a5f1430f1277f29 Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 27 (2009) Candida antarctica lipase B continuous flow epoxidation hydrogen peroxide lipase micro reactor Novozym® 435 peracids Science Q Organic chemistry QD241-441 article 2009 ftdoajarticles https://doi.org/10.3762/bjoc.5.27 2022-12-31T12:57:17Z We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Beilstein Journal of Organic Chemistry 5 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Candida antarctica lipase B continuous flow epoxidation hydrogen peroxide lipase micro reactor Novozym® 435 peracids Science Q Organic chemistry QD241-441 |
spellingShingle |
Candida antarctica lipase B continuous flow epoxidation hydrogen peroxide lipase micro reactor Novozym® 435 peracids Science Q Organic chemistry QD241-441 Charlotte Wiles Marcus J. Hammond Paul Watts The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
topic_facet |
Candida antarctica lipase B continuous flow epoxidation hydrogen peroxide lipase micro reactor Novozym® 435 peracids Science Q Organic chemistry QD241-441 |
description |
We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity. |
format |
Article in Journal/Newspaper |
author |
Charlotte Wiles Marcus J. Hammond Paul Watts |
author_facet |
Charlotte Wiles Marcus J. Hammond Paul Watts |
author_sort |
Charlotte Wiles |
title |
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
title_short |
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
title_full |
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
title_fullStr |
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
title_full_unstemmed |
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
title_sort |
development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes |
publisher |
Beilstein-Institut |
publishDate |
2009 |
url |
https://doi.org/10.3762/bjoc.5.27 https://doaj.org/article/912f776f21244f148a5f1430f1277f29 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 27 (2009) |
op_relation |
https://doi.org/10.3762/bjoc.5.27 https://doaj.org/toc/1860-5397 1860-5397 doi:10.3762/bjoc.5.27 https://doaj.org/article/912f776f21244f148a5f1430f1277f29 |
op_doi |
https://doi.org/10.3762/bjoc.5.27 |
container_title |
Beilstein Journal of Organic Chemistry |
container_volume |
5 |
_version_ |
1766138000929980416 |