The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes

We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidan...

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Bibliographic Details
Published in:Beilstein Journal of Organic Chemistry
Main Authors: Charlotte Wiles, Marcus J. Hammond, Paul Watts
Format: Article in Journal/Newspaper
Language:English
Published: Beilstein-Institut 2009
Subjects:
Candida antarctica lipase B
continuous flow
epoxidation
hydrogen peroxide
lipase
micro reactor
Novozym® 435
peracids
Science
Q
Organic chemistry
QD241-441
Antarc*
Antarctica
Online Access:https://doi.org/10.3762/bjoc.5.27
https://doaj.org/article/912f776f21244f148a5f1430f1277f29
Description
Summary:We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity.

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