Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Three new polyketides, ketidocillinones A−C ( 1 − 3 ), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by usin...

Full description

Bibliographic Details
Published in:Marine Drugs
Main Authors: Mudassir Shah, Chunxiao Sun, Zichao Sun, Guojian Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2020
Subjects:
antarctica sponge-derived fungus
penicillium sp
polyketides
antibacterial activity
Biology (General)
QH301-705.5
Antarc*
Antarctica
Online Access:https://doi.org/10.3390/md18020071
https://doaj.org/article/8f408ee9e2eb49ff8cb00092c228ff14
Description
Summary:Three new polyketides, ketidocillinones A−C ( 1 − 3 ), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1 − 3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C ( 2 and 3 ) exhibited potent antibacterial activity against Pseudomonas aeurigenosa , Mycobacterium phlei , and MRCNS (methicillin-resistant coagulase-negative staphylococci ) with MIC values ranging from 1.56 to 25.00 µg/mL.

Similar Items