Acute disseminated histoplasmosis and endocarditis
Acute disseminated histoplasmosis is a frequent condition in HIV carriers. Thirty-five cases of endocarditis caused by Histoplasma capsulatum have been reported in international literature, and all these descriptions correspond to a context of subacute disseminated histoplasmosis. This paper present...
| Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
|---|---|
| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Universidade de São Paulo (USP)
1998
|
| Subjects: | |
| Online Access: | https://doi.org/10.1590/S0036-46651998000100005 https://doaj.org/article/8e4a082565204cdf86b36ff3936a2a7e |
| Summary: | Acute disseminated histoplasmosis is a frequent condition in HIV carriers. Thirty-five cases of endocarditis caused by Histoplasma capsulatum have been reported in international literature, and all these descriptions correspond to a context of subacute disseminated histoplasmosis. This paper presents the case of a HIV-positive patient with fever, dyspnea, weight loss, vomiting and polyadenopathies to whom histoplasmosis was diagnosed following blood-cultures and isolation of the agent responsible for cutaneous lesions, and in whom aortic-valve vegetations were found during an echocardiogram. The patient was treated with amphotericin B and had a good outcome; subsequent echocardiograms showed no vegetations. Literature on the subject is reviewed, with special emphasis on diagnosis and treatment of previously described cases. Histoplasmose disseminada aguda é uma entidade freqüente nos pacientes portadores do HIV. Na literatura internacional foram descritos trinta e cinco casos de endocardite causada por Histoplasma capsulatum, sendo todas as descrições correspondentes a histoplasmose disseminada subaguda. Este artigo relata o caso de um paciente HIV positivo com febre, dispnea, perda de peso, vômitos e poliadenopatias, no qual foi diagnosticado histoplasmose através de hemoculturas e isolamento do agente responsável das lesões cutâneas, e observadas vegetações na válvula aórtica durante uma ecocardiografia. O doente foi tratado com anfotericina B com boa evolução e as ecocardiografias posteriores não mostraram vegetações. Revisão da literautra sobre o tema foi realizada com ênfase especial quanto ao diagnóstico e tratamento dos casos anteriormente descritos. |
|---|