CD40, autophagy and Toxoplasma gondii

Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles. The dogma had been that the non-fusogenic nature of these vacuoles is irreversible. Recent studies revealed that this dogma is not...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz
Main Author: Carlos S Subauste
Format: Article in Journal/Newspaper
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009
Subjects:
macrophage
lysosome
endosome
IFN-³
nitric oxide
Arctic medicine. Tropical medicine
RC955-962
Microbiology
QR1-502
Arctic
Online Access:https://doi.org/10.1590/S0074-02762009000200020
https://doaj.org/article/8c5f20bfd8d3469e9cb4d186974a4dbe
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Summary:Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles. The dogma had been that the non-fusogenic nature of these vacuoles is irreversible. Recent studies revealed that this dogma is not correct. Cell-mediated immunity through CD40 re-routes the parasitophorous vacuoles to the lysosomal compartment by a process called autophagy. Autophagosome formation around the parasitophorous vacuole results in killing of the T. gondii. CD40-induced autophagy likely contributes to resistance against T. gondii particularly in neural tissue.

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