Epidemiology of bacterial resistance at the Grand Magal of Touba in Senegal

• Published in: Travel Medicine and Infectious Disease
• Main Authors: Ihssane Ouaddane, Ndiaw Goumballa, Xuan Duong Tran, Coumba Diouf, Seydina M. Diene, Jean-Marc Rolain, Cheikh Sokhna, Philippe Gautret
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2024
• Subjects: Grand magal of touba; Pilgrims; Gastrointestinal infections; Bacterial resistance; qPCR; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1016/j.tmaid.2024.102709; https://doaj.org/article/8a98fb22507e4fe9a1763d4076fc39c3

Background: The Grand Magal of Touba (GMT) associates with risks of infection, but no study on the circulation of resistant bacteria has yet been conducted. Materials and methods: qPCR was performed on rectal samples from GMT pilgrims between 2018 and 2021, before and after their participation in the gathering. Rectal samples from between 2018 and 2020 were also cultured on specific media, and antibiotic susceptibility testing was performed. Results: Forty-one of the 296 (13.8%) pilgrims had at least one gastrointestinal symptom and 91/290 (31.4%) acquired pathogenic bacteria, mostly Escherichia coli. A total of 54.7% of pilgrims reported washing their hands more frequently than usual and 89.2% used soap. One hundred and five (36.2%) acquired at least one resistance gene, notably CTX-M A (21.0%), SHV (16.5%) and TEM (8.2%). The strains isolated by culture were mostly E. coli. These bacteria were found to be sensitive to carbapenems and resistant to amoxicillin and amoxicillin-clavulanic acid. The acquisition of enteroaggregative E. coli was independently associated with CTX-M A and TEM acquisition. Conclusion: Pilgrims presented a risk for acquisition of CTX-M A after the GMT. Surveillance of the prevalence of resistant bacteria and the occurrence of associated clinical infections among pilgrims are necessary in the future.