Estudo clínico com o uso do itraconazol em tinha crural, tinha do corpo e tinha do pé interdigital Clinical trial with itraconazole in the treatment of Tinea cruris, Tinea corporis and tinea pedis interdigital

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Clarisse Zaitz, Ligia Rangel B. Ruiz, Elizabeth Maria A. Drullis, Perola Gurfinkel, Mara Aparecida Ciarnuto
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1990
• Subjects: Dermatofitoses; Itraconazol; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651990000400011; https://doaj.org/article/85a2c0fd1c914c73b6703c58e5ee86f9

Os autores estudaram 31 pacientes portadores de tinhas crural, do corpo e do pé interdigital, tratados com 100 mg de itraconazol, administrados junto com o almoço, durante 15 dias. Foram realizadas 3 avaliações clínicas e micológicas: no pré-tratamento, no final do tratamento e 2 semanas após o tratamento. O itraconazol mostrou-se eficaz para o tratamento das dermatofitoses estudadas, na dose empregada, com 100% de cura micológica. Em relação a evolução clínica, houve diminuição estatística significante (teste de Friedman - p < 0,001) dos sinais e sintomas avaliados. Não foi observada ocorrência de efeitos colaterais. The authors studied 31 patients with Tinea cruris, corporis or pedis interdigital. The patients were treated with 100 mg of itraconazole, once a day, during the lunch, for 15 days. Mycological and clinical evaluations were performed at the pre-treatment, by the end of treatment and 2 weeks after finishing the treatment. The results showed that itraconazole is effective for the treatment of dermatophytosis, at the studied posology. with 100% of mycological cure. Clinical evaluation showed a significant reduction (Friedman test - p < 0.001) of signs and symptoms. No side-effect was registered.