| Summary: | Os autores descrevem 8 casos autóctones de doença de Chagas ocorridos em Macapá. Os pacientes pertencem a duas famílias, residindo em bairros distantes. Apresentaram sintomatologia comum como febre, cefaléia, mal-estar geral. A sorologia resultou positiva com títulos de IgM mais elevados que de IgG em 75% dos casos apresentados. Outros exames específicos para a doença foram realizados. Os xenodiag- nósticos foram positivos em 25% dos casos quando foi isolada a cepa de Trypanosoma cruzi. Os autores demonstram ainda que uma das formas infectadas do T. cruzi pertence ao zimodema 3 e sugerem a possibilidade de transmissão "per os". The present paper describes 8 autochthonous cases of Chagas' disease in Macapa City, Federal Territory ofAmapa, Brazil. The patients belonged to two different families and lived in different areas of the city. All the patients had general symptoms such as headache, fever and malaise. The serology was positive for T. cruzi The titres of IgM were higher than IgG in 6 of the cases. Other specific tests for Chagas'disease were carried out. Xenodiagnosis was positive in 2 of the cases and the T. cruzi strains were isolated in this instance. The authors had also demonstrated that one of the isolates of T. cruzi was zymodeme 3 and suggest that transmission "per os" most likely accounted for concomitant acute cases within the same family.
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