Antibody response to Salmonella typhi lw human Schistosomiasis mansoni

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Maria Imaculada Muniz-Junqueira, José Tavares-Neto, Aluizio Prata, Carlos Eduardo Tosta
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1996
• Subjects: Esquistosomose rnansoni; Salmonella typhi; Antígenos O e H; Salmonelose septicêmica prolongada associada à esquistossomose; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821996000500006; https://doaj.org/article/7b7763b40b36485f821f302f238848c7

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.