Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model
Objective: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters. Methods: Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients. Results: Manix® altered the bioavailability param...
| Published in: | Asian Pacific Journal of Tropical Biomedicine |
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| Main Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014
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| Subjects: | |
| Online Access: | https://doi.org/10.12980/APJTB.4.2014C400 https://doaj.org/article/7b2d110a65394dc8b72bb5ab72dfb181 |
| Summary: | Objective: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters. Methods: Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients. Results: Manix® altered the bioavailability parameters of pefloxacin as thus, maximal concentration (Cmax) of pefloxacin (0.91 ± 0.31) μg/mL occurred at time to reach maximal concentration (tmax) 4.0 h while in the group that received Manix® alongside pefloxacin Cmax was (0.22 ± 0.08) μg/mL at tmax 1.0 h respectively. The area under curve of pefloxacin alone was (7.83 ± 5.14) μg/h/mL while with Manix® was (2.60 ± 0.08) μg/h/mL. There was a significant difference between Cmax, tmax and area under curve between pefloxacin alone and pefloxacin after Manix® pre-treatment (P<0.05). Conclusions: The concurrent use of Manix® and pefloxacin has been found to compromise the therapeutic effectiveness of pefloxacin which could lead to poor clinical outcomes in patients. |
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