Clinical outcomes of hospitalized patients with chikungunya fever: A retrospective analysis

Objective: To describe the prognostic and clinical profile of hospitalized patients with chikungunya virus (CHIKV) infection focusing on renal outcomes. Methods: This is a cross-sectional study including all patients with confirmed chikungunya fever (CHIKF) admitted to 3 different high-complexity ho...

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Bibliographic Details
Published in:Asian Pacific Journal of Tropical Medicine
Main Authors: Lucas Lobo Mesquita, Ênio Simas Macedo, Sérgio Luiz Arruda Parente Filho, Francisca Lillyan Christyan Nunes Beserra, Evelyne Santana Girão, Juliana Mandato Ferragut, Roberto da Justa Pires Neto, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2021
Subjects:
arbovirus infections
chikungunya fever
acute kidney injury
elderly
mortality
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doi.org/10.4103/1995-7645.312519
https://doaj.org/article/792e8043f23d424d8fc98be7f2b07f1c
Description
Summary:Objective: To describe the prognostic and clinical profile of hospitalized patients with chikungunya virus (CHIKV) infection focusing on renal outcomes. Methods: This is a cross-sectional study including all patients with confirmed chikungunya fever (CHIKF) admitted to 3 different high-complexity hospitals in Fortaleza, Brazil between January 2016 and June 2017. Data analysis was carried out to evaluate correlation between clinical profile and outcomes. Results: Fifty-five patients were included, with a median age of 77 (IQR=21) years, and 23 (41.82%) were male. Twenty-five patients (45.45%, 25/55) developed acute kidney injury (AKI), and 15 (60.00%, 15/25) were classified as KDIGO 1, 1 (4.00%) as KDIGO 2, and 9 (36.00%) as KDIGO 3. The overall mortality was 34.54% whilst AKI-related mortality was 64.00% (16/25). Both AKI and encephalitis were associated with higher mortality. Patients who died were significantly older [82 (IQR=12) years vs. 70 (IQR= 28.75) years, P<0.001)]. In the multivariate analysis, abdominal pain was associated with an increased risk of severe AKI (OR=5.33, 95% CI=1.11–25.64, P=0.037) and AKI was an independent risk factor of death (OR=12.06, 95% CI=2.55–57.15, P=0.002). Recovery of renal function was similar among the different age groups. Conclusions: AKI is present in half of the study population and is an independent risk factor of death. Thus, renal function should be carefully monitored in hospitalized patients with CHIKV infection.

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