I/D Polymorphism of the ACE Gene in Kazakh Origin Patients with Mitral Heart Disease
Purpose: Purpose of study is to reflect the characteristics of the comparative between Kazakh nationality in patients with mitral heart disease, healthy people and literature data of the ACE gene I/D polymorphism Material and Methods: Total of 138 individual were included in our study. Of these, 70...
| Main Authors: | , |
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| Format: | Article in Journal/Newspaper |
| Language: | English Turkish |
| Published: |
Cukurova University
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/78ddebb706124978bcec8505f7d31b5a |
| Summary: | Purpose: Purpose of study is to reflect the characteristics of the comparative between Kazakh nationality in patients with mitral heart disease, healthy people and literature data of the ACE gene I/D polymorphism Material and Methods: Total of 138 individual were included in our study. Of these, 70 were patients with mitral valvular disease (42,83 +/- 1,06 years ) and 68 were healthy (40,24 +/- 0,87 years). All subjects were of Kazakh origin and was not involved with each other in terms of kinship. Result: 70 patients and 68 healthy people, all of whom were Kazakh origin, were genotyped for I/D polymorphism of ACE gene. In healthy individuals, the frequency of carriers having only genotype II was 35,29% (n = 24), only ID was 50,00% (n = 34), and only DD genotype was 14,71% (n = 10). Among patients with mitral valvular disease the heart rate of people with carriers II genotype was only 25,72% (n = 18), only the ID genotype carriers were 61,43% (n = 43), and DD genotype were 12,86% (n = 9) . I allele frequency equal to 56,50% (n = 79), D alleles - 43,60% (n = 61). Differences between the frequency distribution of genotypes in patients compared to healthy individuals were insignificant ( and #61539; 2 = 1.933, p = 0.380). I allele frequency in all healthy individuals was 60,30% (n = 82), D allele - 39,70% (n = 54), patients with mitral valvular disease were - 56.50% and 43.60%, respectively. Difference in distribution of alleles of the ACE gene was also not reliable ( and #61539; 2 = 0.280, p = 0.590). The frequency distribution of genotypes and alleles of the ACE gene we have studied was comparable with the data distribution of healthy Kazakhs and Kazakhs population from other authors (Musagalieva AT, Shalharova JC, Kozhanova OV, Baitasova NB), as well as Kazakhs living in Xinjiang province in China (Wang XF).But, our data on the genotypes and alleles did not differ significantly from those of the Uighurs, Yakuts, Hindus (Baitasova NB, Grigorieva L., Joseph A.). The difference of the frequency distribution of ... |
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