Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review

Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis rem...

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Bibliographic Details
Published in:Asian Pacific Journal of Tropical Medicine
Main Authors: Nur Ellene Mat Luwi, Suhana Ahmad, Ahmad Suhaimi Nurfatihah Azlyna, Asyikin Nordin, Maria Elena Sarmiento, Armando Acosta, Mohd Nor Azmi, Vuk Uskoković, Rohimah Mohamud, Ramlah Kadir
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2022
Subjects:
liposomes
tuberculosis vaccine
adjuvant
delivery system
tuberculosis
Arctic medicine. Tropical medicine
RC955-962
Arctic
Calmette
Online Access:https://doi.org/10.4103/1995-7645.332806
https://doaj.org/article/788c5b83ccd149c69d3aedcdb25f0755
Description
Summary:Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis remains an important health problem that requires the development of an effective vaccine, especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin (BCG) one developed 100 years ago. This review focuses on the different applications of liposomes toward achieving this goal. Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

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