REACTIVITY OF ANTI-GP43 ANTIBODIES FROM PARACOCCIDIOIDES BRASILIENSIS ANTISERUM WITH EXTRACTS FROM CUTANEOUS LESIONS OF LOBO'S DISEASE: PRELIMINARY NOTE

We demonstrated through several immunochemical tests the presence of GP-43 from P. brasiliensis in extracts of cutaneous lesions from Jorge Lobo's disease. This glicoprotein is one of the immunodominant antigens in this species, and is used to identify it. The demonstration of GP-43 tissues inf...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: Mônica Scarpelli Martinelli VIDAL, Selma Aliotti PALACIOS, Natalina TAKAHASHI DE MELO, Carlos da Silva LACAZ
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 1997
Subjects:
Paracoccidioides brasiliensis
Anti-GP-43 Antibodies
Lobo's disease
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1590/S0036-46651997000100007
https://doaj.org/article/76e735ca245f4a51a6dedf9ceb0e45a8
Description
Summary:We demonstrated through several immunochemical tests the presence of GP-43 from P. brasiliensis in extracts of cutaneous lesions from Jorge Lobo's disease. This glicoprotein is one of the immunodominant antigens in this species, and is used to identify it. The demonstration of GP-43 tissues infected by the agent of Jorge Lobo's disease is an additional evidence for classifying it in the genera Paracoccidioides, species loboi Através de várias provas imunoquímicas foi demonstrada a presença da GP-43 em extratos de lesões cutâneas da doença de Jorge Lobo. A glicoproteína de 43 kDa é um dos antígenos dominantes do Paracoccidioides brasiliensis, permitindo a identificação desta espécie fúngica. A demonstração da GP-43 em tecidos infectados com o agente da doença de Jorge Lobo, constitui mais um argumento para colocá-lo no gênero Paracoccidioides, espécie loboi

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