Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental
Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors dens...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
1995
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S0036-46651995000100009 https://doaj.org/article/72dc5bd335414c38a878e5e76996f5e7 |
id |
ftdoajarticles:oai:doaj.org/article:72dc5bd335414c38a878e5e76996f5e7 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:72dc5bd335414c38a878e5e76996f5e7 2024-09-09T19:27:29+00:00 Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental Julio E. Enders Patricia Paglini Alicia R. Fernandez Fernanda Marco José A. Palma 1995-02-01T00:00:00Z https://doi.org/10.1590/S0036-46651995000100009 https://doaj.org/article/72dc5bd335414c38a878e5e76996f5e7 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000100009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000100009 0036-4665 1678-9946 https://doaj.org/article/72dc5bd335414c38a878e5e76996f5e7 Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 1, Pp 59-63 (1995) Chagas' disease beta receptors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1995 ftdoajarticles https://doi.org/10.1590/S0036-46651995000100009 2024-08-05T17:49:31Z Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção). O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM) respeito do controle (Kd = 3.759 ± 0.212 nM) p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) Revista do Instituto de Medicina Tropical de São Paulo 37 1 59 63 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas' disease beta receptors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chagas' disease beta receptors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Julio E. Enders Patricia Paglini Alicia R. Fernandez Fernanda Marco José A. Palma Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
topic_facet |
Chagas' disease beta receptors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção). O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM) respeito do controle (Kd = 3.759 ± 0.212 nM) p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica. |
format |
Article in Journal/Newspaper |
author |
Julio E. Enders Patricia Paglini Alicia R. Fernandez Fernanda Marco José A. Palma |
author_facet |
Julio E. Enders Patricia Paglini Alicia R. Fernandez Fernanda Marco José A. Palma |
author_sort |
Julio E. Enders |
title |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title_short |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title_full |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title_fullStr |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title_full_unstemmed |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title_sort |
cardiac beta-receptors in experimental chagas' disease receptores beta cardíacos na doença de chagas experimental |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0036-46651995000100009 https://doaj.org/article/72dc5bd335414c38a878e5e76996f5e7 |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Aguda |
geographic_facet |
Arctic Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 1, Pp 59-63 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000100009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000100009 0036-4665 1678-9946 https://doaj.org/article/72dc5bd335414c38a878e5e76996f5e7 |
op_doi |
https://doi.org/10.1590/S0036-46651995000100009 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
37 |
container_issue |
1 |
container_start_page |
59 |
op_container_end_page |
63 |
_version_ |
1809896909401227264 |