Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the abs...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S. Leutou, Yern-Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N. Maloney, Dong-Chan Oh, Inho Yang, Hayoung Hwang, Sang-Jip Nam
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2018
Subjects:
Streptomyces sp
cold water natural product
marine natural product
zizaane-type sesquiterpenoid
Biology (General)
QH301-705.5
Antarctic
Antarc*
Online Access:https://doi.org/10.3390/md16040130
https://doaj.org/article/72b21dfdf2b14bcea07d24dd6575ff67
Description
Summary:Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

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