Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Sayada Dilruba, M.M. Hasibuzzaman, Mashiur Rahman, Nayan Chandra Mohanto, Sharmin Aktar, Atiqur Rahman, Md Imam Hossain, Abu Shadat Mohammod Noman, Farjana Nikkon, Zahangir Alam Saud, Khaled Hossain
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017
• Subjects: Sodium arsenite; Raphanus sativus leaves; Ameliorating effect; Serum indices; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.1016/j.apjtb.2017.09.001; https://doaj.org/article/6e197e4ed61d4ccba95addeb832cd2ae

Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments. Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (P < 0.05) higher in Sa-treated mice than those in the control group. RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly (P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly (P < 0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.