Translational implications of bradyarrhythmia in hibernating brown bears

Abstract The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the act...

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Bibliographic Details
Published in:Physiological Reports
Main Authors: Lisa A. Gottlieb, Alina L. Evans, Boris Fuchs, Ole Fröbert, Anna Björkenheim
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2023
Subjects:
bradyarrhythmia
brown bear
hibernation
sinus arrest
sinus node disease
sinus pause
Physiology
QP1-981
Ursus arctos
Online Access:https://doi.org/10.14814/phy2.15550
https://doaj.org/article/6dc14936e28f494ab445f8c3ec5f05a0
Description
Summary:Abstract The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.

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