The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis

Background: By the year 2030, it will be seven more times difficult and seven times more of 14,600 pills to treat one person with drug resistant tuberculosis (TB) if we fail in the use of ‘Omics therapy’. A curated database of the National Centre for Biotechnology Institute (NCBI): Comprehensive Ant...

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Bibliographic Details
Published in:Microbes and Infectious Diseases
Main Authors: Taiwo Aderibigbe, Adeoti Micheal
Format: Article in Journal/Newspaper
Language:English
Published: Zagazig University, Faculty of Medicine 2022
Subjects:
omics
card
mycobacterium tuberculosis
multi-drugs resistant
whole genome sequence
Infectious and parasitic diseases
RC109-216
Antarc*
Antarctica
Online Access:https://doi.org/10.21608/mid.2021.73675.1145
https://doaj.org/article/63c85367d179401383be2462ea67fa04
Description
Summary:Background: By the year 2030, it will be seven more times difficult and seven times more of 14,600 pills to treat one person with drug resistant tuberculosis (TB) if we fail in the use of ‘Omics therapy’. A curated database of the National Centre for Biotechnology Institute (NCBI): Comprehensive Antibiotic Resistance Database (CARD) provides high-through-put referenced information on antibiotics resistance.Methods:This study employed a less expensive but high accuracy software-based approach; Comprehensive Antibiotics Resistance Database to identify the resistance genes within the genomes of Mycobacterium tuberculosis across the five continents. Thirty complete genomes of Mycobacterium tuberculosis were retrieved and their respective accession numbers and locations were categorized into Perfect and Strict genes. Results: The least number of Mycobacterium tuberculosis complete genome sequences were retrieved from the America followed by Antarctica and Africa with 10%, 10%, 25% prevalence respectively. The continents with the highest number of sequences were Asia and Europe which account for 25% and 33.3% respectively. The prevalence of genes categorized under the strict category from CARD database with mdsB, mdsA, AAC(6')-Iaa, sdiA, golS TEM-1, tetW , ANT(4')-Ib, had 100% prevalence each (present in all the 30 complete genome sequences retrieved), arlR, arlS, mepR, mgrA had the prevalence rates of 25%, each, mepA, Lmrs, FosB had the prevalence rates of 33.3% each.

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