Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

Four new anthraquinone derivatives, namely saliniquinones G−I ( 1 – 3 ) and heraclemycin E ( 4 ), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, includi...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Luning Zhou, Xuedong Chen, Chunxiao Sun, Yimin Chang, Xiaofei Huang, Tianjiao Zhu, Guojian Zhang, Qian Che, Dehai Li
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2021
Subjects:
anthraquinone derivatives
GNPS
Nocardiopsis aegyptia
MRCNS
Biology (General)
QH301-705.5
Antarctic
The Antarctic
Antarc*
Online Access:https://doi.org/10.3390/md19100575
https://doaj.org/article/5feb3290083e4ed2a798c79ec0403a8a
Description
Summary:Four new anthraquinone derivatives, namely saliniquinones G−I ( 1 – 3 ) and heraclemycin E ( 4 ), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.

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