Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

Abstract Background With the aim of discovering new natural active extracts against malaria parasites, Icacina senegalensis was selected after an ethnopharmacological survey conducted on plants used in traditional malaria treatment in Senegal. Methods Different concentrations of the plant extract an...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Candolfi Ermanno, Diop Yérim M, Zhao Minjie, Ennahar Saïd, Fall Ibrahima, Perrotey Sylvie, Sarr Serigne O, Marchioni Eric
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2011
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-10-85
https://doaj.org/article/5ecac0249d324bdba190a3065729095f
Description
Summary:Abstract Background With the aim of discovering new natural active extracts against malaria parasites, Icacina senegalensis was selected after an ethnopharmacological survey conducted on plants used in traditional malaria treatment in Senegal. Methods Different concentrations of the plant extract and fractions were tested on synchronized Plasmodium falciparum cultures at the ring stage using the parasite lactate dehydrogenase assay. Their haemolytic activity and in vitro cytoxicity were evaluated. The chromatographic profiles of active fractions were also established. Results The plant extract and fractions revealed anti-plasmodial activity (IC 50 < 5 μg/mL) with no toxicity (Selectivity indexes >10). The dichloromethane fraction showed stronger anti-plasmodial activity than the total extract. Conclusion Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research.

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