A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice
The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profil...
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Online Access: | https://doi.org/10.1016/j.jff.2013.11.003 https://doaj.org/article/5cb636b398e14175baaecdd0f7e3a25b |
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ftdoajarticles:oai:doaj.org/article:5cb636b398e14175baaecdd0f7e3a25b 2023-05-15T14:01:25+02:00 A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri 2014-01-01T00:00:00Z https://doi.org/10.1016/j.jff.2013.11.003 https://doaj.org/article/5cb636b398e14175baaecdd0f7e3a25b EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1756464613002570 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2013.11.003 https://doaj.org/article/5cb636b398e14175baaecdd0f7e3a25b Journal of Functional Foods, Vol 6, Iss , Pp 623-630 (2014) Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism Nutrition. Foods and food supply TX341-641 article 2014 ftdoajarticles https://doi.org/10.1016/j.jff.2013.11.003 2022-12-31T15:23:39Z The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet. Metabolic pathways that were down-regulated included β-oxidation, glucose metabolism, and amino acid catabolism. In contrast, the mitochondrial electron transport chain pathway was upregulated. Krill powder affected more pathways involved in protein metabolism than krill oil. Thus, a krill powder supplemented diet had potent and specific effects on energy metabolism and oxidative phosphorylation at the gene level. This indicates that krill powder supplementation could be an approach to prevent decline in mitochondrial respiratory chain function. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Euphausia superba Directory of Open Access Journals: DOAJ Articles Antarctic Journal of Functional Foods 6 623 630 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism Nutrition. Foods and food supply TX341-641 |
spellingShingle |
Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism Nutrition. Foods and food supply TX341-641 Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
topic_facet |
Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism Nutrition. Foods and food supply TX341-641 |
description |
The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet. Metabolic pathways that were down-regulated included β-oxidation, glucose metabolism, and amino acid catabolism. In contrast, the mitochondrial electron transport chain pathway was upregulated. Krill powder affected more pathways involved in protein metabolism than krill oil. Thus, a krill powder supplemented diet had potent and specific effects on energy metabolism and oxidative phosphorylation at the gene level. This indicates that krill powder supplementation could be an approach to prevent decline in mitochondrial respiratory chain function. |
format |
Article in Journal/Newspaper |
author |
Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri |
author_facet |
Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri |
author_sort |
Bodil Bjørndal |
title |
A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
title_short |
A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
title_full |
A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
title_fullStr |
A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
title_full_unstemmed |
A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
title_sort |
krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
publisher |
Elsevier |
publishDate |
2014 |
url |
https://doi.org/10.1016/j.jff.2013.11.003 https://doaj.org/article/5cb636b398e14175baaecdd0f7e3a25b |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill Euphausia superba |
genre_facet |
Antarc* Antarctic Antarctic Krill Euphausia superba |
op_source |
Journal of Functional Foods, Vol 6, Iss , Pp 623-630 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1756464613002570 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2013.11.003 https://doaj.org/article/5cb636b398e14175baaecdd0f7e3a25b |
op_doi |
https://doi.org/10.1016/j.jff.2013.11.003 |
container_title |
Journal of Functional Foods |
container_volume |
6 |
container_start_page |
623 |
op_container_end_page |
630 |
_version_ |
1766271240774877184 |