Epidemic of Invasive Pneumococcal Disease, Western Canada, 2005–2009

In Canada before 2005, large outbreaks of pneumococcal disease, including invasive pneumococcal disease caused by serotype 5, were rare. Since then, an epidemic of serotype 5 invasive pneumococcal disease was reported: 52 cases during 2005, 393 during 2006, 457 during 2007, 104 during 2008, and 42 d...

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Bibliographic Details
Published in:Emerging Infectious Diseases
Main Authors: Gregory J. Tyrrell, Marguerite Lovgren, Quazi Ibrahim, Sipi Garg, Linda Chui, Tyler J. Boone, Carol Mangan, David M. Patrick, Linda Hoang, Greg B. Horsman, Paul Van Caeseele, Thomas J. Marrie
Format: Article in Journal/Newspaper
Language:English
Published: Centers for Disease Control and Prevention 2012
Subjects:
Streptococcus pneumoniae
serotype 5
epidemic
invasive pneumococcal disease
bacteria
Canada
Medicine
R
Infectious and parasitic diseases
RC109-216
First Nations
Online Access:https://doi.org/10.3201/eid1805.110235
https://doaj.org/article/59d130fa0ad04a4e970b0652ce935f93
Description
Summary:In Canada before 2005, large outbreaks of pneumococcal disease, including invasive pneumococcal disease caused by serotype 5, were rare. Since then, an epidemic of serotype 5 invasive pneumococcal disease was reported: 52 cases during 2005, 393 during 2006, 457 during 2007, 104 during 2008, and 42 during in 2009. Of these 1,048 cases, 1,043 (99.5%) occurred in the western provinces of Canada. Median patient age was 41 years, and most (659 [59.3%]) patients were male. Most frequently representing serotype 5 cases (compared with a subset of persons with non–serotype 5 cases) were persons who were of First Nations heritage or homeless. Restriction fragment-length polymorphism typing indicated that the epidemic was caused by a single clone, which multilocus sequence typing identified as sequence type 289. Large pneumococcal epidemics might go unrecognized without surveillance programs to document fluctuations in serotype prevalence.

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