Anti-Candida and anti-quorum sensing activity of airborne microorganisms detected by a rapid method

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Andria Lopes Cruz, Fabiana Silva de Souza, Maxwel Adriano Abegg
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: Candida sp; Chromobacterium violaceum; Quorum sensing; Antimicrobials; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0152-2018; https://doaj.org/article/5844716f70d74c11bccf8adab2abd083

Abstract INTRODUCTION: Introducing new antibiotics to the clinic is critical. METHODS: We adapted a plate method described by Kawaguchi and coworkers in 20131 for detecting inhibitory airborne microorganisms. RESULTS: We obtained 51 microbial colonies antagonist to Chromobacterium violaceum, purified and retested them, and of these, 39 (76.5%) were confirmed. They comprised 24 bacteria, 13 fungi, and 2 yeasts. Among the fungi, eight (61.5%) produced active extracts. Among the bacterial, yeast, and fungal strains, 17 (44.7%) and 12 (31.6%) were active against Candida albicans and Candida parapsilosis, respectively. CONCLUSIONS: The proposed screening method is a rapid strategy for discovering potential antibiotic producers.