A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.

Trial registration ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751.

Bibliographic Details
Published in:PLOS Neglected Tropical Diseases
Main Authors: Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, Kristine Lillebø, Dag Harald Skutlaberg, Anne Berit Guttormsen, Anton Zavialov, Sari Paavilainen, Hanne Søyland, Marianne Sævik, Astrid Rykkje Heien, Marit Gjerde Tellevik, Eileen Barry, Nina Langeland, Halvor Sommerfelt, Kurt Hanevik
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2019
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Arctic
Online Access:https://doi.org/10.1371/journal.pntd.0007823
https://doaj.org/article/57d1742137074c0aad8c3dc3640999be
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spelling ftdoajarticles:oai:doaj.org/article:57d1742137074c0aad8c3dc3640999be 2023-05-15T14:51:48+02:00 A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses. Sunniva Todnem Sakkestad Hans Steinsland Steinar Skrede Kristine Lillebø Dag Harald Skutlaberg Anne Berit Guttormsen Anton Zavialov Sari Paavilainen Hanne Søyland Marianne Sævik Astrid Rykkje Heien Marit Gjerde Tellevik Eileen Barry Nina Langeland Halvor Sommerfelt Kurt Hanevik 2019-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007823 https://doaj.org/article/57d1742137074c0aad8c3dc3640999be EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007823 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007823 https://doaj.org/article/57d1742137074c0aad8c3dc3640999be PLoS Neglected Tropical Diseases, Vol 13, Iss 10, p e0007823 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007823 2022-12-31T07:08:54Z Trial registration ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 10 e0007823
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Sunniva Todnem Sakkestad
Hans Steinsland
Steinar Skrede
Kristine Lillebø
Dag Harald Skutlaberg
Anne Berit Guttormsen
Anton Zavialov
Sari Paavilainen
Hanne Søyland
Marianne Sævik
Astrid Rykkje Heien
Marit Gjerde Tellevik
Eileen Barry
Nina Langeland
Halvor Sommerfelt
Kurt Hanevik
A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
topic_facet Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
description Trial registration ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751.
format Article in Journal/Newspaper
author Sunniva Todnem Sakkestad
Hans Steinsland
Steinar Skrede
Kristine Lillebø
Dag Harald Skutlaberg
Anne Berit Guttormsen
Anton Zavialov
Sari Paavilainen
Hanne Søyland
Marianne Sævik
Astrid Rykkje Heien
Marit Gjerde Tellevik
Eileen Barry
Nina Langeland
Halvor Sommerfelt
Kurt Hanevik
author_facet Sunniva Todnem Sakkestad
Hans Steinsland
Steinar Skrede
Kristine Lillebø
Dag Harald Skutlaberg
Anne Berit Guttormsen
Anton Zavialov
Sari Paavilainen
Hanne Søyland
Marianne Sævik
Astrid Rykkje Heien
Marit Gjerde Tellevik
Eileen Barry
Nina Langeland
Halvor Sommerfelt
Kurt Hanevik
author_sort Sunniva Todnem Sakkestad
title A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
title_short A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
title_full A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
title_fullStr A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
title_full_unstemmed A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
title_sort new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic escherichia coli diarrhea - dose optimization, clinical outcomes, and cd4+ t cell responses.
publisher Public Library of Science (PLoS)
publishDate 2019
url https://doi.org/10.1371/journal.pntd.0007823
https://doaj.org/article/57d1742137074c0aad8c3dc3640999be
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source PLoS Neglected Tropical Diseases, Vol 13, Iss 10, p e0007823 (2019)
op_relation https://doi.org/10.1371/journal.pntd.0007823
https://doaj.org/toc/1935-2727
https://doaj.org/toc/1935-2735
1935-2727
1935-2735
doi:10.1371/journal.pntd.0007823
https://doaj.org/article/57d1742137074c0aad8c3dc3640999be
op_doi https://doi.org/10.1371/journal.pntd.0007823
container_title PLOS Neglected Tropical Diseases
container_volume 13
container_issue 10
container_start_page e0007823
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