A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, Kristine Lillebø, Dag Harald Skutlaberg, Anne Berit Guttormsen, Anton Zavialov, Sari Paavilainen, Hanne Søyland, Marianne Sævik, Astrid Rykkje Heien, Marit Gjerde Tellevik, Eileen Barry, Nina Langeland, Halvor Sommerfelt, Kurt Hanevik
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2019
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic
• Online Access: https://doi.org/10.1371/journal.pntd.0007823; https://doaj.org/article/57d1742137074c0aad8c3dc3640999be

Trial registration ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751.