Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage

Abstract Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas...

Full description

Bibliographic Details
Published in:Food Science & Nutrition
Main Authors: Adrian S. Siregar, Marie Merci Nyiramana, Eun‐Jin Kim, Eui‐Jung Shin, Min Seok Woo, Jin‐Mok Kim, Si‐Hyang Park, Jong Ryeal Hahm, Yeung Joon Choi, Dawon Kang
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2022
Subjects:
alcohols
functional foods
inflammation
liver injury
oxidative stress
oyster broth concentrate
Nutrition. Foods and food supply
TX341-641
Crassostrea gigas
Online Access:https://doi.org/10.1002/fsn3.2847
https://doaj.org/article/5628a6f4ae2f438da0e6a0b142968921
Description
Summary:Abstract Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by‐product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single‐EtOH‐binge‐drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca2+ concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF‐κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH‐induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects.

Similar Items