"In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Shen Lin Yang, Silvia Maria Di Santi, Vicente Amato Neto, Antonio Augusto Baillot Moreira, Pedro Luiz Silva Pinto, Marcos Boulos, Rubens Campos, Eunice José de Sant'Ana, Mario Shiroma
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1988
• Subjects: Plasmodium falciparum; Violeta de genciana - ação "in vitro"; Malária transfusional-profilaxia; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651988000100003; https://doaj.org/article/542bbc8721204c4b9683f1b58a9a177c

In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria.