"In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites

In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturati...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: Shen Lin Yang, Silvia Maria Di Santi, Vicente Amato Neto, Antonio Augusto Baillot Moreira, Pedro Luiz Silva Pinto, Marcos Boulos, Rubens Campos, Eunice José de Sant'Ana, Mario Shiroma
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 1988
Subjects:
Plasmodium falciparum
Violeta de genciana - ação "in vitro"
Malária transfusional-profilaxia
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1590/S0036-46651988000100003
https://doaj.org/article/542bbc8721204c4b9683f1b58a9a177c
Description
Summary:In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria.

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