Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations

• Published in: Diabetes mellitus
• Main Authors: Elena Vital'evna Titovich, Tamara Leonidovna Kuraeva, G I Danilova, L P Alekseev, M N Boldyreva, A N Nikitin, O N Ivanova, Sergey Alexandrovich Prokofiev, Lyubov' Iosifovna Zilberman, N M Tsitlidze, Valery Vyacheslavovich Nosikov, Ivan Ivanovich Dedov
• Format: Article in Journal/Newspaper
• Language: English; Russian
• Published: Endocrinology Research Centre 2009
• Subjects: type 1 diabetes mellitus; polymorphism of class ii hla genes; population studies; Nutritional diseases. Deficiency diseases; RC620-627; Yakutia; Yakuts
• Online Access: https://doi.org/10.14341/2072-0351-5448; https://doaj.org/article/5323be91c99544c4a6a3e858d767d171

Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (RR