Treatment outcomes in new pulmonary tuberculosis cases depending on the main genotypes of Mycobacterium tuberculosis in the Republic of Sakha (Yakutia)

The objective: to study treatment efficacy in new pulmonary tuberculosis patients depending on the genotypes of M. tuberculosis in the Republic of Sakha (Yakutia).Subjects and methods. The authors studied the clinical course and outcomes of 312 bacteriologically confirmed new pulmonary tuberculosis...

Full description

Bibliographic Details
Published in:Tuberculosis and Lung Diseases
Main Authors: N. E. Evdokimov, M. K. Vinokurovа, S. N. Zhdаnovа, O. B. Ogаrkov, A. F. Krаvchenko, E. D. Sаvilov
Format: Article in Journal/Newspaper
Language:Russian
Published: New Terra Publishing House 2021
Subjects:
туберкулез легких
генотипы mycobacterium tuberculosis
субтип cc2/w148
субтип s256
впервые выявленные больные
исходы туберкулеза
Diseases of the respiratory system
RC705-779
Sakha
Republic of Sakha
Yakutia
Online Access:https://doi.org/10.21292/2075-1230-2021-99-1-41-47
https://doaj.org/article/5255e8c3213d4bbea05b79c24071d0c1
Description
Summary:The objective: to study treatment efficacy in new pulmonary tuberculosis patients depending on the genotypes of M. tuberculosis in the Republic of Sakha (Yakutia).Subjects and methods. The authors studied the clinical course and outcomes of 312 bacteriologically confirmed new pulmonary tuberculosis cases among patients admitted to hospital in 2010-2014. Molecular genetic tests included deletion analysis of RD105 and RD207 regions of DNA of the pathogen followed by MIRU-VNTR genotyping at 24 loci.Results. In the Republic of Sakha (Yakutia), the Bejing and S genotypes are of epidemic importance, these genotypes prevail among drug resistance mycobacteria. Tuberculosis caused by the Bejing genotype had multiple (MDR) and extensive drug resistance (XDR) in 30.6% of cases, its subtype CC2/W148 - in 85.3%. The S genotype was accompanied by MDR/XDR in 69.7% of cases, subtype S256 - in 78.9%. The treatment of patients was highly efficient according to the criteria of sputum conversion (92%) and cavities healing (89.4%). The lowest rates were observed in case of tuberculosis caused by the Bejing and S genotypes due to their subtypes CC2/W148 and S256. Clinical cure of new pulmonary tuberculosis caused by the Bejing genotype was achieved in 73.4% of cases, by subtype CC2/W148 - in 41.2% with a significantly higher proportion of treatment failures and lethal outcomes of tuberculosis than in other subtypes of this genotype. With the S genotype, the clinical cure was achieved in 72.7% of patients, with no significant difference in the incidence of unfavorable outcomes in patients with subtype S256.

Similar Items