Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Dehai Li, Tianjiao Zhu, Qianqun Gu, Guangwei Wu, Aiqun Lin
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2013
Subjects:
chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Biology (General)
QH301-705.5
Antarctic
Antarc*
Online Access:https://doi.org/10.3390/md11041399
https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b
id ftdoajarticles:oai:doaj.org/article:512ae40f11644c3ba09ac808f4a4761b
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spelling ftdoajarticles:oai:doaj.org/article:512ae40f11644c3ba09ac808f4a4761b 2023-05-15T13:38:09+02:00 Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 Dehai Li Tianjiao Zhu Qianqun Gu Guangwei Wu Aiqun Lin 2013-04-01T00:00:00Z https://doi.org/10.3390/md11041399 https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b EN eng MDPI AG http://www.mdpi.com/1660-3397/11/4/1399 https://doaj.org/toc/1660-3397 doi:10.3390/md11041399 1660-3397 https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b Marine Drugs, Vol 11, Iss 4, Pp 1399-1408 (2013) chlorinated eremophilane sesquiterpene Antarctic deep-sea derived fungus Penicillium sp Biology (General) QH301-705.5 article 2013 ftdoajarticles https://doi.org/10.3390/md11041399 2022-12-30T22:33:15Z A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Marine Drugs 11 4 1399 1408
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Biology (General)
QH301-705.5
spellingShingle chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Biology (General)
QH301-705.5
Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
topic_facet chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Biology (General)
QH301-705.5
description A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
format Article in Journal/Newspaper
author Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
author_facet Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
author_sort Dehai Li
title Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_short Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_fullStr Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full_unstemmed Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_sort four new chloro-eremophilane sesquiterpenes from an antarctic deep-sea derived fungus, penicillium sp. pr19n-1
publisher MDPI AG
publishDate 2013
url https://doi.org/10.3390/md11041399
https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b
geographic Antarctic
geographic_facet Antarctic
genre Antarc*
Antarctic
genre_facet Antarc*
Antarctic
op_source Marine Drugs, Vol 11, Iss 4, Pp 1399-1408 (2013)
op_relation http://www.mdpi.com/1660-3397/11/4/1399
https://doaj.org/toc/1660-3397
doi:10.3390/md11041399
1660-3397
https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b
op_doi https://doi.org/10.3390/md11041399
container_title Marine Drugs
container_volume 11
container_issue 4
container_start_page 1399
op_container_end_page 1408
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