Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Dehai Li, Tianjiao Zhu, Qianqun Gu, Guangwei Wu, Aiqun Lin
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2013
Subjects:
chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Biology (General)
QH301-705.5
Antarctic
Antarc*
Online Access:https://doi.org/10.3390/md11041399
https://doaj.org/article/512ae40f11644c3ba09ac808f4a4761b
Description
Summary:A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.

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