The avirulence of the cultivated PF strain of Trypanosoma cruzi: VI - The effect of antilymphocytic serum in dogs

The use of antilymphocytic serum (ALS) in dogs suppressed the immune response of a vacclnated and simultaneously ALS treated animal, increased the infectivity of a virulent strain and did not induce a typical infectian-disease in 3 dogs receiving the serum and the avirulent PF strain. Soro antilinfo...

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Bibliographic Details
Main Author: Humberto Menezes
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1974
Subjects:
Online Access:https://doaj.org/article/4ed2682663f04c1dbd3c2993b90aca33
Description
Summary:The use of antilymphocytic serum (ALS) in dogs suppressed the immune response of a vacclnated and simultaneously ALS treated animal, increased the infectivity of a virulent strain and did not induce a typical infectian-disease in 3 dogs receiving the serum and the avirulent PF strain. Soro antilinfocitário ALS anti-cão mostrou-se capaz de agravar uma infecção produzida pela cepa virulenta Y do Trypanosoma cruzi (Graph I, Table 4). Cães vacinados com a cepa avirulenta PF não demonstraram, 9 meses após o início da experiência, qualquer sinal de infecção-doença, apesar das altas doses de soro recebidas (Graph I, Tables 1-3). O soro é um poderoso imunosupressor capaz de impedir o desenvolvimento de defesas imunitárias em um animal injetado com a cepa PF e simultaneamente tratado com o mesmo (Table 6).