Alzheimer’s disease serum lipids levels in Siberia

Background: Previous studies examining the association of serum lipids levels with the risk for development of Alzheimer disease (AD) have been inconclusive. Objective: To evaluate the serum lipids levels in persons suffering from AD. Methods: 147 patients suffering from AD (according to NINCDS/ADRD...

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Bibliographic Details
Main Authors: A. V. Sukhanov, M. V. Ivanova, Yu. I. Ragino, M. I. Voevoda, Yu. P. Nikitin
Format: Article in Journal/Newspaper
Language:Russian
Published: Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 2011
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Online Access:https://doaj.org/article/4d9317b2b8a447b2b089bbba4c838b67
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Summary:Background: Previous studies examining the association of serum lipids levels with the risk for development of Alzheimer disease (AD) have been inconclusive. Objective: To evaluate the serum lipids levels in persons suffering from AD. Methods: 147 patients suffering from AD (according to NINCDS/ADRDA criteria) of both sexes from the Novosibirsk city were examined. Concentration of serum lipids were assessed by enzymatic method. Cognitive functions were determined by Mini-mental State Examination Scale (MMSE). Results: Patients’ serum lipids levels were corresponded to norms according to European and American Recommendations. Patients’ serum lipids levels were not statistically significant distinguished from those in long-livers from the Novosibirsk city and Yakutia. Statistically significant associations between serum total cholesterol, low-density lipoprotein cholesterol (LDL-CH), high-density lipoprotein cholesterol (HDL-CH) levels and patients’ age, as well as MMSE score were not revealed in correlation analysis. Conclusion: Serum lipids levels were not associated with risk for development of AD in examined patients’ group.