Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S

Abstract Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccin...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Katya Galactionova, Thomas A. Smith, Melissa A. Penny
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2021
Subjects:
Malaria vaccines
Modelling and simulation
Economic evaluation
Malaria control
Product development
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/s12936-021-03973-y
https://doaj.org/article/4c687905428b492e833955da49e3b20f
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Summary:Abstract Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.

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