Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever.

Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (...

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Bibliographic Details
Published in:PLoS Neglected Tropical Diseases
Main Authors: Jane Cardosa, Mong How Ooi, Phaik Hooi Tio, David Perera, Edward C Holmes, Khatijar Bibi, Zahara Abdul Manap
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2009
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Arctic
Online Access:https://doi.org/10.1371/journal.pntd.0000423
https://doaj.org/article/4bdab6b01b8c4880929dd00312ee21b9
Description
Summary:Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975.

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