T cell-dependent immunodepression in vivo in Schistosoma mansoni infected patients

T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular imm...

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Bibliographic Details
Main Authors: Maria Imaculada Muniz-Junqueira, Carlos Eduardo Tosta, Aluizio Prata
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1990
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Online Access:https://doaj.org/article/476ad39c75a2461288dff7dfa3b49122
Description
Summary:T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular immunodepression was related to worm load and spleen size. This non specific T-cell immunodepression may represent a serious constraint to the elimination of intracellular pathogens both in hepatosplenic or hepatointestinal schistosomiasis. A imunidade celular foi avaliada em 29 pacientes com as formas hepatoesplênica ou hepatointestinal, da esquistossomose mansoni, através de testes intradérmicos com antígenos não relacionados ao Schistosoma. Imunodepressão foi detectada em 26% dos pacientes com a forma hepatointestinal e em 50% daqueles com a forma hepatoesplênica. A imunodepressão celular foi relacionada com a carga parasitária e o tamanho do baço. Esta imunodepressão celular pode dificultar a eliminação de patógenos intracelulares tanto na forma hepatoesplênica quanto na forma hepatointestinal da esquistossomose.