Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Ana Carolina Etrusco Zaroni Santos, Michele Luglio, Artur Figueiredo Delgado, Constance Dell Santo Vieira Schuwartz, Heloísa Helena Sousa Marques, Clarissa Carvalho de Miranda Valões, Maria Andreina Cabrera Dominguez, Werther Brunow de Carvalho, Clovis Artur Silva, Amaro Nunes Duarte-Neto
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP)
• Subjects: Myocardial calcification; Sepsis; Neisseria meningitides; Lupus; Intensive care; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/s1678-9946201961039; https://doaj.org/article/47545b71e89f4193a864c28eddd972a6

ABSTRACT Acute petrified myocardium associated with septic shock, diagnosed by autopsy has rarely been described. A 15-year-old adolescent male was diagnosed with childhood-onset systemic lupus erythematosus. One year later, he was hospitalized with fever, myalgia, headache, arthritis, vomiting, dyspnea and was diagnosed with sepsis secondary to bronchopneumonia and meningitis. Blood culture identified Neisseria meningitidis serogroup Y. Despite antibiotics and intensive therapeutic measures, he died after 29 days of hospitalization. The autopsy revealed necrotic cardiomyocytes with dystrophic calcification and interstitial fibrosis.