Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Bakhshwin Duaa M., Alhalabi Foziya W., Barasheed Mohamad Omar, Bakhshwin Ahmed M., Jamal Maha H., Bazuhair Mohammed A., Kamel Fatemah O., Magadmi Rania M., Damanhouri Zoheir A, Alsaggaf Samar M.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2024
• Subjects: alzheimer’s disease; cognitive function; glucagonlike peptide-1; liraglutide; memantine; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.4103/apjtb.apjtb_937_23; https://doaj.org/article/457bd036c20c4a3f955f97ba2512f8a6

Objective: To assess the effect of memantine combined with liraglutide on aluminum chloride (AlCl3) and D-galactose (D-GAL)- induced neurotoxicity in rats. Methods: Male Wistar rats were divided into 5 groups of 5 animals each: the positive control, the negative control, the memantine-treated group, the liraglutide-treated group, and the combination group treated with memantine and liraglutide. AlCl3 and D-GAL were used to induce neurotoxicity. Behavioral tests, brain beta-amyloid protein, and oxidative stress biomarkers were evaluated. Results: The Morris water maze test indicated an enhanced memory in the combination group. Moreover, the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain tissue. Neuronal inflammation and oxidative stress biomarkers were significantly reduced, and the levels of antioxidant parameters were enhanced. Conclusions: The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.