Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts' meeting on serum biomarkers.

The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public heal...

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Bibliographic Details
Published in:PLOS Neglected Tropical Diseases
Main Authors: Kirsten E Wiens, Barbara Jauregui, Benjamin F Arnold, Kathryn Banke, Djibril Wade, Kyla Hayford, Adriana Costero-Saint Denis, Robert H Hall, Henrik Salje, Isabel Rodriguez-Barraquer, Andrew S Azman, Guy Vernet, Daniel T Leung, Collaboration on Integrated Biomarkers Surveillance
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2022
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Online Access:https://doi.org/10.1371/journal.pntd.0010657
https://doaj.org/article/44b4c85016744926bb86f5c36ed7ca7f
Description
Summary:The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group's insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.