Factors associated with the intermediate probability of heart failure with preserved ejection fraction on the H 2 FPEF score in asymptomatic patients in rotation work conditions in the Arctic

• Published in: Cardiovascular Therapy and Prevention
• Main Authors: A. S. Vetoshkin, N. P. Shurkevich, A. A. Simonyan, L. I. Gapon, M. A. Kareva
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2022
• Subjects: артериальная гипертония; промежуточная вероятность сердечной недостаточности с сохраненной фракцией выброса; шкала h 2 fpef; арктика; Diseases of the circulatory (Cardiovascular) system; RC666-701; Arctic; Yamburg; Арктика
• Online Access: https://doi.org/10.15829/1728-8800-2022-3167; https://doaj.org/article/41f0235681264fd5863cb8b6b392ea8c

Aim. To study the factors associated with the intermediate probability of heart failure (HF) with preserved ejection fraction (HFpEF) according to the H2FPEF score (Heavy; Hypertensive; Atrial Fibrillation; Pulmonary Hypertension; Elder; Filling Pressure) in asymptomatic patients in rotation work conditions in the Arctic.Material and methods. In the polar village of Yamburg (68° 21’ 40” northern latitude), 100 men and 80 women with grade 1, 2 hypertension and normotensive persons were examined on the basis of the Medical Unit of OOO Gazprom Dobycha Yamburg. All patients underwent echocardiography using generally accepted methods of imaging and data processing, according to European Society of Echocardiography guidelines. To calculate the probability of HFpEF, the H2FPEF score was used. The Bruce protocol treadmill test was performed. The SF-36 (Health Status Survey) questionnaire for assessment of life quality was used.Results. Group 1 included 95 male and female patients with a low probability of HF (H2FPEF score — 0-1), group 2 — 85 patients of both sexes with an intermediate probability of HF (H2FPEF score — 2-5). Group 2 patients were older (p=0,038), worked longer on a shift (p=0,0143), and had higher ambulatory systolic (p=0,0001) and diastolic blood pressure (p=0,0013) with a higher body mass index (BMI) (p=0,0001). Based on the odds ratio (OR) analysis, the factor most strongly influencing the intermediate probability of HFpEF was BMI (OR=1,261, 95% confidence interval (CI): 1,140-1,393). SF-36 questionnaire revealed intergroup differences only on the role functioning scale (p=0,013) with lower values in group 2. In the logistic regression model, dyspnea during the treadmill test occupied a leading position as follows: OR=8,952; 95% CI: 3,454-15,197 (p<0,0001). The second place was taken by inotropic reserve value (OR=1,020; 95% CI: 1,006-1,035 (p=0,005), which was higher in group 2 and was regarded as one of the compensatory mechanisms for adapting to stress. In the group 2, echocardiography revealed ...