Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line

• Main Authors: Khdary NH, Alangari AA, Katubi KM, Alanazi M, Alhassan A, Alzahrani SD, Khan Z, Alanazi IO
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2023
• Subjects: ginger; gingerol; gingerol-complexes; colon cancer; tumor cell line; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; sami
• Online Access: https://doaj.org/article/405e73fe8a2848a9bbe9cb20ffe22a64

Nezar H Khdary,1 Abdulaziz A Alangari,2 Khadijah M Katubi,3 Mohammad Alanazi,4 Ahmed Alhassan,1 Sami D Alzahrani,1 Zahid Khan,4 Ibrahim O Alanazi1 1Institute of Materials Science, King Abdulaziz City for Science and Technology, Riyadh, Kingdom of Saudi Arabia; 2College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; 4Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Nezar H Khdary, Institute of Materials Science, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel [phone], Email [e-mail] Ibrahim O Alanazi, Aging institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, Tel [phone], Email [e-mail]: Herbs are excellent sources of medicinal substances, and their curative abilities have been recognized to treat many ailments and are used for example as antioxidants, analgesics, anti-inflammatories, antipyretics, and many other medicinal uses. The properties of natural compounds and their health effects have been studied extensively, especially those that originate from plant sources such as ginger. The ginger plant contains many chemical compounds, such as 6-gingerol, which is characterized by containing active groups such as carbonyl and hydroxide, which can be attached to metal molecules. This is what was done in this study, where the formation of complexes with a group of metals was studied and their effect on cancer cells was investigated. These complexes will open new horizons for further study of medicinal uses.Methods: The synthesis of gingerol-metal complexes was carried out by conjugating gingerol molecules with Ag, Au, Cd, Co, Cu, Ni, and Zn metal ions. The extracted gingerol was transferred to culture tubes and deionized water-DMSO were added followed by sonication. ...