Susceptibility to amphotericin B of Candida spp. strains isolated in Ceará, Northeastern Brazil

Introduction Amphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB. Methods For broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Cecília Rocha da Silva, Hemerson Iury Ferreira Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2013
Subjects:
Amphotericin B
Candida spp
Protocol M27-A3
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doi.org/10.1590/0037-8682-1060-2013
https://doaj.org/article/3e778bfde28c4ef9817bcab7ce89b69d
Description
Summary:Introduction Amphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB. Methods For broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptible when they exhibited MIC≤1.0µg/ml. Results None of the strains showed an MIC greater than 0.25µg/ml. Conclusions Further works are necessary, with a higher number of strains, to assess the validity of the results used in this study.

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