A Sustainable Green Enzymatic Method for Amide Bond Formation

A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the nee...

Full description

Bibliographic Details
Published in:Molecules
Main Authors: György Orsy, Sayeh Shahmohammadi, Enikő Forró
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2023
Subjects:
sustainable enzymatic strategy
direct amide synthesis
green solvent
CALB
carboxylic acid
amine
Organic chemistry
QD241-441
Antarc*
Antarctica
Online Access:https://doi.org/10.3390/molecules28155706
https://doaj.org/article/3e60c90c96274f45879d6b7396e5e793
Description
Summary:A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis.

Similar Items