Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region Resistência do Plasmodium vivax pela cloroquina (R2) e mefloquina (R3) na amazônia Brasileira

We report for the first time a patient with malaria due to Plasmodium vivax who showed R2 resistance to chloroquine and R3 resistance to mefloquine in the Brazilian Amazon region based on WHO clinical criteria for diagnosis of malaria resistance. Failure was observed with unsupervised oral chloroqui...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Maria das Graças C. Alecrim, Wilson Alecrim, Vanize Macêdo
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1999
Subjects:
Plasmodium vivax
Resistência a drogas
Resistência à cloroquina
Resistência à mefloquina
Drug resistance
Chloroquine resistance
Mefloquine resistance
Arctic medicine. Tropical medicine
RC955-962
Arctic
Sob’
Online Access:https://doi.org/10.1590/S0037-86821999000100013
https://doaj.org/article/3e0d6d10774b49b0935947ed258fa9ff
Description
Summary:We report for the first time a patient with malaria due to Plasmodium vivax who showed R2 resistance to chloroquine and R3 resistance to mefloquine in the Brazilian Amazon region based on WHO clinical criteria for diagnosis of malaria resistance. Failure was observed with unsupervised oral chloroquine, chloroquine under rigorous supervision and mefloquine in the same scheme. Finally, the patient was cured with oral artesunate. Estamos relatando pela primeira vez um paciente com malária por Plasmodium vivax que mostrou resistência R2 à cloroquina e resistência R3 à mefloquina na Amazônia brasileira, de acordo com os critérios clínicos da OMS para resistência da malária. A falha foi observada com cloroquina oral, não supervisionada, cloroquina oral administrada sob rigorosa supervisão e com mefloquina no mesmo esquema. A paciente curou com o artesunato oral.

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