The Anti-Obesity Potential of Cyperus rotundus Extract Containing Piceatannol, Scirpusin A and Scirpusin B Rhizomes: Preclinical and Clinical Evaluations

• Main Authors: Majeed M, Nagabhushanam K, Bhat B, Ansari M, Pandey A, Bani S, Mundkur L
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2022
• Subjects: cyperus rotundus; piceatannol; scirpusin a; scirpusin b; obesity; adipogenesis; lipid levels; leptin; randomized clinical trial; Specialties of internal medicine; RC581-951; Bani; Lakshmi; sami
• Online Access: https://doaj.org/article/3db4d50d788f4fe996f4eb2e2253bdf6

Muhammed Majeed,1,2 Kalyanam Nagabhushanam,3 Beena Bhat,4 Mohammad Ansari,4 Anjali Pandey,5 Sarang Bani,5 Lakshmi Mundkur5 1Research and Development, Sami-Sabinsa Group Limited, Bangalore, India; 2Research and Development, Sabinsa Corporation, East Windsor, NJ, USA; 3Research and Development, Natural Product Chemistry Sabinsa Corporation, East Windsor, NJ, USA; 4Research and Development, Phytochemistry, Sami-Sabinsa Group Limited, Bangalore, India; 5Research and Development, Biological Research, Sami-Sabinsa Group Limited, Bangalore, IndiaCorrespondence: Lakshmi MundkurSami-Sabinsa Group Limited, 19/1, 19/2, 1st Main, 2nd Phase, Peenya Industrial Area Bangalore, Bengaluru, Karnataka, 560058, India, Tel [phone], Email [e-mail]: Obesity is a complex medical problem that increases the risk of other diseases like diabetes, cardiovascular diseases, and fatty liver disease. The present study evaluated the efficacy and safety of Cyperus rotundus rhizome extract (CRE), standardized to contain Piceatannol, Scirpusin A, and Scirpusin B (5% total Stilbenoids) in overweight individuals. The mechanism of activity was evaluated in a diet-induced mice model of obesity and adipocytes in vitro.Materials and Methods: The efficacy, safety, and tolerability of CRE were evaluated in 30 obese individuals with a BMI of 30 to 40 kg/m2 for 90 days in a randomized, double-blind, parallel-group, placebo-controlled study. In vitro studies were carried out in differentiated 3T3 L1 adipocytes, and the therapeutic efficacy was evaluated in high-fat diet-induced obese mice.Results: The pilot clinical study showed a reduction in body weight with a significant decrease in waist circumference and BMI. The serum lipid profile showed a significant improvement in CRE-treated individuals. The extract was well tolerated, and no adverse effects were reported at the end of the study. CRE showed a dose-dependent adipogenesis reduction in vitro with an IC50 value of 9.39 μg/mL, while oral administration of CRE reduced ...