A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum / Plasmodium vivax infections

Abstract Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. viv...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Manning Laurens, Rosanas-Urgell Anna, Laman Moses, Edoni Henry, McLean Catriona, Mueller Ivo, Siba Peter, Davis Timothy ME
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2012
Subjects:
Plasmodium vivax
Post mortem biopsy
PCR
Cerebral malaria
Children
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-11-107
https://doaj.org/article/3c87a9893b7e4a7b89be59dade4b4807
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Summary:Abstract Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.

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