Pulmonary hemorrhage in dengue: differential diagnosis with acute viral respiratory syndromes including COVID-19

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Leonardo Antonio Aguiar, Ana Carolina de Morais Oliveira-Scussel, Jerônimo Coelho de Menezes, Priscila Barbosa Idaló, Lara Élida Guazzeli de Freitas, Luzia Beatriz Ribeiro Zago, Cristina da Cunha Hueb Barata de Oliveira, Naiara Clemente Tavares, Edward José de Oliveira, Marcos Vinícius da Silva, Luciana de Almeida Silva Teixeira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2022
• Subjects: Dengue; Pulmonary hemorrhage; Viral respiratory syndromes; SARS-COV-2; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/s1678-9946202264013; https://doaj.org/article/38d259c1869044d2bd990b7db8ab4f1c

ABSTRACT Clinical similarities among viral diseases become even more relevant considering the current scenario, especially in Brazil, where there is a high incidence of these diseases and overlapping seasonality. We report the case of a patient with acute clinical manifestations composed of predominant respiratory symptoms and alveolar hemorrhage in which three etiologies (dengue, influenza and COVID-19) were investigated concomitantly. Only the diagnosis of dengue was confirmed. Then, the patient’s immunological profile in response to stimulation of mononuclear cells with dengue virus antigen was analyzed in an attempt to identify specific characteristics that could be associated with the clinical manifestation.